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STOCK TICKER:

MAJOR GURUS:
David Einhorn
Bill Ackman
Bill Miller
Steven Cohen
Jim Simons

Sofinnova Investments, Inc. INSTITUTION : Sofinnova Investments, Inc.
Sofinnova Investments, Inc. Portfolio (reported on 2019-11-14)
Company (links to holding history) Ticker Value On
2019-09-30
No of Shares % of portfolio
Ascendis Pharma A/S    (ADR) 106,903,000 1,109,874 9.66%
Natera    (COMM) 101,698,000 3,100,560 9.19%
Amarin    (ADR) AMRN 78,958,000 5,208,305 7.13%
Nextcure, Inc    (COMM) 77,799,000 2,521,856 7.03%
Y-mAbs Therapeutics, Inc    (COMM) 54,837,000 2,104,278 4.95%
Spark Therapeutics    (COMM) ONCE 46,674,000 481,270 4.22%
Principia Biopharma    (COMM) 40,023,000 1,417,258 3.61%
ObsEva SA    (COMM) 39,564,000 4,749,623 3.57%
Coherus BioSciences    (COMM) CHRS 39,167,000 1,933,221 3.54%
Merus N.V.    (COMM) 34,946,000 1,961,039 3.15%
Karuna Therapeutics, Inc.    (COMM) 28,223,000 1,729,352 2.55%
Audentes Therapeutics    (COMM) 26,226,000 933,640 2.37%
Nucana Biomed Ltd    (Ordinary Shares) 17,376,000 2,400,000 1.57%
Nucana Biomed Ltd    (ADR) 16,411,000 2,266,666 1.48%
Health Care Select Sector SPDR    (COMM) 14,078,000 156,200 1.27%
Bristol-Myers Squibb Co    (COMM) BMY 12,811,000 252,637 1.15%
Vertex Pharmaceuticals Inc    (COMM) VRTX 10,970,000 64,750 0.99%
Iterum Therapeutics    (COMM) 9,962,000 1,726,514 0.90%
Allergan plc    (COMM) AGN 9,622,000 57,176 0.86%
Amgen Inc    (COMM) AMGN 9,433,000 48,748 0.85%
Neurocrine Biosciences Inc    (COMM) NBIX 9,118,000 101,188 0.82%
Acceleron Pharma Inc    (COMM) XLRN 8,519,000 215,621 0.77%
Health Care Select Sector SPDR    (COMM) 8,202,000 91,000 0.74%
United Therapeutics Corp    (COMM) UTHR 8,172,000 102,468 0.73%
Allergan plc    (COMM) AGN 8,159,000 48,481 0.73%
Chiasma    (COMM) 8,070,000 1,630,221 0.72%
Kiniksa Pharmaceuticals, Ltd    (COMM CL A) 7,852,000 922,700 0.70%
Pfizer Inc    (COMM) PFE 7,671,000 213,496 0.69%
Bristol-Myers Squibb Co    (COMM) BMY 7,109,000 140,193 0.64%
Entasis Therapeutics Holdings Inc.    (COMM) 7,034,000 1,180,178 0.63%
Reata Pharmaceuticals Inc    (COMM) 6,322,000 78,744 0.57%
Reata Pharmaceuticals Inc    (COMM) 6,279,000 78,200 0.56%
Vertex Pharmaceuticals Inc    (COMM) VRTX 5,933,000 35,022 0.53%
Amgen Inc    (COMM) AMGN 5,235,000 27,051 0.47%
Halozyme Therapeutics Inc    (COMM) HALO 5,211,000 335,988 0.47%
TG Therapeutics Inc    (COMM) TGTX 5,141,000 915,606 0.46%
PTC Therapeutics Inc    (COMM) PTCT 5,131,000 151,707 0.46%
Neurocrine Biosciences Inc    (COMM) NBIX 5,070,000 56,260 0.45%
Allergan plc    (COMM) AGN 4,843,000 28,776 0.43%
Health Care Select Sector SPDR    (COMM) 4,759,000 52,800 0.43%
Acceleron Pharma Inc    (COMM) XLRN 4,727,000 119,653 0.42%
United Therapeutics Corp    (COMM) UTHR 4,535,000 56,861 0.41%
Pfizer Inc    (COMM) PFE 4,480,000 124,684 0.40%
Bristol-Myers Squibb Co    (COMM) BMY 4,337,000 85,519 0.39%
Sarepta Therapeutics Inc    (COMM) SRPT 4,231,000 56,170 0.38%
MacroGenics Inc    (COMM) MGNX 3,892,000 304,990 0.35%
Aimmune Therapeutics Inc    (COMM) 3,835,000 183,145 0.34%
Vertex Pharmaceuticals Inc    (COMM) VRTX 3,713,000 21,918 0.33%
Reata Pharmaceuticals Inc    (COMM) 3,581,000 44,600 0.32%
Reata Pharmaceuticals Inc    (COMM) 3,475,000 43,278 0.31%
Kadmon Holdings Inc    (COMM) KDMN 3,436,000 1,363,414 0.31%
Dermira Inc    (COMM) DERM 3,342,000 522,952 0.30%
Amgen Inc    (COMM) AMGN 3,193,000 16,501 0.28%
Beigene Ltd    (COMM) 3,184,000 26,000 0.28%
Fate Therapeutics Inc    (COMM) FATE 3,130,000 201,540 0.28%
MyoKardia Inc    (COMM) 3,126,000 59,935 0.28%
Neurocrine Biosciences Inc    (COMM) NBIX 3,085,000 34,231 0.27%
Halozyme Therapeutics Inc    (COMM) HALO 2,892,000 186,446 0.26%
Acceleron Pharma Inc    (COMM) XLRN 2,884,000 72,988 0.26%
TG Therapeutics Inc    (COMM) TGTX 2,853,000 508,086 0.25%
PTC Therapeutics Inc    (COMM) PTCT 2,847,000 84,185 0.25%
United Therapeutics Corp    (COMM) UTHR 2,766,000 34,685 0.25%
Heron Therapeutics Inc    (COMM) HRTX 2,718,000 146,921 0.24%
Amicus Therapeutics Inc    (COMM) FOLD 2,677,000 333,834 0.24%
Pfizer Inc    (COMM) PFE 2,602,000 72,427 0.23%
Dicerna Pharmaceuticals Inc    (COMM) DRNA 2,600,000 181,024 0.23%
Akebia Therapeutics Inc    (COMM) AKBA 2,511,000 640,462 0.22%
Biomarin Pharmaceutical Inc    (COMM) BMRN 2,477,000 36,752 0.22%
Zymeworks Inc    (COMM) 2,430,000 98,001 0.21%
Sarepta Therapeutics Inc    (COMM) SRPT 2,348,000 31,169 0.21%
MacroGenics Inc    (COMM) MGNX 2,211,000 173,299 0.19%
Reata Pharmaceuticals Inc    (COMM) 2,139,000 26,647 0.19%
Aimmune Therapeutics Inc    (COMM) 2,128,000 101,630 0.19%
Reata Pharmaceuticals Inc    (COMM) 2,071,000 25,800 0.18%
Aclaris Therapeutics    (COMM) 2,064,000 1,911,573 0.18%
Biomarin Pharmaceutical Inc    (COMM) BMRN 2,024,000 30,029 0.18%
XBiotech Inc    (COMM) 1,972,000 188,528 0.17%
Kadmon Holdings Inc    (COMM) KDMN 1,959,000 777,390 0.17%
Beigene Ltd    (COMM) 1,861,000 15,200 0.16%
Dermira Inc    (COMM) DERM 1,854,000 290,195 0.16%
Halozyme Therapeutics Inc    (COMM) HALO 1,764,000 113,733 0.15%
MyoKardia Inc    (COMM) 1,759,000 33,728 0.15%
Forty Seven Inc    (COMM) 1,750,000 272,541 0.15%
Orchard Therapeutics PLC    (ADR) 1,750,000 147,330 0.15%
TG Therapeutics Inc    (COMM) TGTX 1,740,000 309,936 0.15%
Fate Therapeutics Inc    (COMM) FATE 1,737,000 111,838 0.15%
PTC Therapeutics Inc    (COMM) PTCT 1,737,000 51,353 0.15%
Foamix Pharmaceuticals Ltd    (COMM) FOMX 1,701,000 559,617 0.15%
Otonomy Inc    (COMM) OTIC 1,640,000 686,172 0.14%
Portola Pharmaceuticals Inc    (COMM) PTLA 1,588,000 59,191 0.14%
Calithera Biosciences Inc    (COMM) CALA 1,567,000 507,012 0.14%
Amicus Therapeutics Inc    (COMM) FOLD 1,566,000 195,220 0.14%
Amicus Therapeutics Inc    (COMM) FOLD 1,555,000 193,920 0.14%
ArQule Inc    (COMM) ARQL 1,466,000 204,507 0.13%
Akebia Therapeutics Inc    (COMM) AKBA 1,452,000 370,288 0.13%
Dicerna Pharmaceuticals Inc    (COMM) DRNA 1,443,000 100,454 0.13%
Sarepta Therapeutics Inc    (COMM) SRPT 1,437,000 19,075 0.12%
Zymeworks Inc    (COMM) 1,417,000 57,154 0.12%
Homology Medicines Inc    (COMM) 1,398,000 77,265 0.12%
MacroGenics Inc    (COMM) MGNX 1,318,000 103,265 0.11%
Synlogic Inc.    (COMM) 1,317,000 574,972 0.11%
Aimmune Therapeutics Inc    (COMM) 1,298,000 61,995 0.11%
Cytokinetics Inc    (COMM) CYTK 1,268,000 111,433 0.11%
Mirati Therapeutics Inc    (COMM) MRTX 1,267,000 16,267 0.11%
Foamix Pharmaceuticals Ltd    (COMM) FOMX 1,243,000 408,895 0.11%
Biomarin Pharmaceutical Inc    (COMM) BMRN 1,221,000 18,115 0.11%
Apellis Pharmaceuticals, Inc    (COMM) 1,194,000 49,580 0.10%
Kadmon Holdings Inc    (COMM) KDMN 1,182,000 468,954 0.10%
Dermira Inc    (COMM) DERM 1,131,000 177,021 0.10%
XBiotech Inc    (COMM) 1,118,000 106,899 0.10%
Otonomy Inc    (COMM) OTIC 1,118,000 467,940 0.10%
Beigene Ltd    (COMM) 1,078,000 8,800 0.09%
Fate Therapeutics Inc    (COMM) FATE 1,059,000 68,222 0.09%
MyoKardia Inc    (COMM) 1,057,000 20,263 0.09%
Orchard Therapeutics PLC    (ADR) 1,022,000 85,987 0.09%
Forty Seven Inc    (COMM) 998,000 155,394 0.09%
Heron Therapeutics Inc    (COMM) 995,000 53,800 0.08%
Kala Pharmaceuticals Inc    (COMM) 949,000 249,447 0.08%
Syndax Pharmaceuticals Inc    (COMM) 948,000 126,896 0.08%
Align Technology Inc    (COMM) ALGN 944,000 5,216 0.08%
Heron Therapeutics Inc    (COMM) HRTX 920,000 49,723 0.08%
Calithera Biosciences Inc    (COMM) CALA 885,000 286,326 0.08%
Dicerna Pharmaceuticals Inc    (COMM) DRNA 880,000 61,277 0.07%
ArQule Inc    (COMM) ARQL 856,000 119,395 0.07%
Akebia Therapeutics Inc    (COMM) AKBA 848,000 216,441 0.07%
Zymeworks Inc    (COMM) 825,000 33,283 0.07%
Syndax Pharmaceuticals Inc    (COMM) 786,000 105,200 0.07%
BioCryst Pharmaceuticals Inc    (COMM) BCRX 778,000 271,493 0.07%
Homology Medicines Inc    (COMM) 776,000 42,877 0.07%
Savara Inc    (COMM) 727,000 274,180 0.06%
Cytokinetics Inc    (COMM) CYTK 704,000 61,838 0.06%
Mirati Therapeutics Inc    (COMM) MRTX 703,000 9,027 0.06%
Foamix Pharmaceuticals Ltd    (COMM) FOMX 701,000 230,742 0.06%
Otonomy Inc    (COMM) OTIC 678,000 283,853 0.06%
Applied Therapeutics Inc    (COMM) 674,000 61,330 0.06%
XBiotech Inc    (COMM) 661,000 63,236 0.05%
Orchard Therapeutics PLC    (ADR) 595,000 50,089 0.05%
Forty Seven Inc    (COMM) 587,000 91,363 0.05%
Heron Therapeutics Inc    (COMM) HRTX 562,000 30,358 0.05%
Applied Therapeutics Inc    (COMM) 553,000 50,350 0.04%
Kala Pharmaceuticals Inc    (COMM) 549,000 144,378 0.04%
Syndax Pharmaceuticals Inc    (COMM) 548,000 73,313 0.04%
Align Technology Inc    (COMM) ALGN 546,000 3,017 0.04%
Calithera Biosciences Inc    (COMM) CALA 530,000 171,514 0.04%
ArQule Inc    (COMM) ARQL 498,000 69,485 0.04%
PDS Biotechnology Corporation    (COMM) 482,000 142,635 0.04%
Homology Medicines Inc    (COMM) 473,000 26,155 0.04%
Syndax Pharmaceuticals Inc    (COMM) 445,000 59,600 0.04%
BioCryst Pharmaceuticals Inc    (COMM) BCRX 441,000 153,942 0.03%
Cytokinetics Inc    (COMM) CYTK 429,000 37,721 0.03%
Mirati Therapeutics Inc    (COMM) MRTX 429,000 5,506 0.03%
Sunesis Pharmaceuticals Inc    (COMM) 424,000 589,441 0.03%
Savara Inc    (COMM) 424,000 160,124 0.03%
Syndax Pharmaceuticals Inc    (COMM) 389,000 52,100 0.03%
Applied Therapeutics Inc    (COMM) 333,000 30,324 0.03%
Kala Pharmaceuticals Inc    (COMM) 321,000 84,381 0.02%
Syndax Pharmaceuticals Inc    (COMM) 321,000 42,941 0.02%
Align Technology Inc    (COMM) ALGN 320,000 1,767 0.02%
Syndax Pharmaceuticals Inc    (COMM) 263,000 35,200 0.02%
BioCryst Pharmaceuticals Inc    (COMM) BCRX 262,000 91,299 0.02%
Sunesis Pharmaceuticals Inc    (COMM) 248,000 344,373 0.02%
Savara Inc    (COMM) 246,000 93,014 0.02%
Syndax Pharmaceuticals Inc    (COMM) 226,000 30,300 0.02%
Sunesis Pharmaceuticals Inc    (COMM) 144,000 200,133 0.01%
Syndax Pharmaceuticals Inc    (COMM) 131,000 17,600 0.01%
Total Value As 2019-09-30: 1,106,014,000 SEC FILING
* Portfolios do not reflect changes after reporting
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MAJOR GURUS:
Warren Buffett
John Paulson
George Soros

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